In clinical trials for weight loss, 4 cases of acute pancreatitis were confirmed by adjudication (vs 1 placebo case). One case of chronic pancreatitis was confirmed. In clinical trials for type 2 diabetes, acute pancreatitis was confirmed by adjudication in 7 (0.3 cases per 100 patient years) and 8 patients (0.27 per 100 patient years) in 2 separate trials (compared to 3 and 10 placebo treated patients, respectively). Very common (10% or more): Nausea (up to 44%), increased amylase (up to 13%), increased lipase (up to 22%), diarrhea (up to 30%), vomiting (up to 24%), constipation (up to 24%), abdominal pain (up to 20%),Ĭommon (1% to 10%): Dyspepsia, eructation, flatulence, gastroesophageal reflux disease, abdominal distention, gastroenteritis, gastroesophageal reflux disease, gastritis, gastroenteritis (viral)įrequency not reported: Acute and necrotizing pancreatitis, chronic pancreatitis Postmarketing reports: Medullary thyroid cancerĬases of Medullary thyroid cancer (MTC) have been reported in patients treated with liraglutide in the postmarketing period the data in these reports is insufficient to establish or exclude a causal relationship between MTC and GLP-1 receptor agonist use in humans. The most commonly reported adverse reactions have included nausea, vomiting, diarrhea, abdominal pain, and constipation. stomach discomfort, swelling, tenderness, or upsetĪpplies to semaglutide: oral tablet, subcutaneous solution.
Side effect or affect professional#
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.Ĭheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common These side effects may go away during treatment as your body adjusts to the medicine. Some side effects of semaglutide may occur that usually do not need medical attention. pain in the stomach, side, or abdomen, possibly radiating to the back.large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs.Although not all of these side effects may occur, if they do occur they may need medical attention.Ĭheck with your doctor immediately if any of the following side effects occur while taking semaglutide: More common Counsel patients regarding the potential risk of MTC and symptoms of thyroid tumors Serious side effects of OzempicĪlong with its needed effects, semaglutide (the active ingredient contained in Ozempic) may cause some unwanted effects. It is unknown whether semaglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined.Semaglutide is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Warning: Risk of Thyroid C-Cell TumorsIn rodents, semaglutide causes thyroid C-cell tumors.
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